Cestrum diurnum possessing ursolic acid as major active constituent was standardized and evaluated for antioxidant and hepatoprotective activities. The methanolic extract of leaves of C. diurnum (CDM) showed antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide. The CCl4 treated rats showed a significant alteration in the levels of hepatoprotective (ALAT, ASAT and LDH) and antioxidant (CAT, LPO and Glu-T) parameters. Administration of CDM (100, 200 and 400 mg/kg for 7 days, p.o.) to CCl4 treated rats showed dose-dependent effect. CDM (200 and 400 mg/kg) mitigate the biochemical changes caused by CCl4 treatment and CDM-400 mg/kg results were comparable to standard silymarin.
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